Antihyperalgesic Effect of a Cannabis Sativa Extract in a Rat Model of Neuropathic Pain: Mechanisms Involved
Francesca Comelli et al. "Antihyperalgesic Effect of a Cannabis sativa Extract in a Rat Model of Neuropathic Pain: Mechanisms Involved," Phytotherapy Research 22, issue 8:1017-24 (published online July 10. 2008)
For years, medical marijuana patients and advocates have argued that the plant works better than single-cannabinoid pharmaceuticals such as Marinol. This study suggests they've been right all along. Researchers measured relief of neuropathic pain in rats, comparing a marijuana extract containing a large amount of cannabidiol (CBD), some THC, and other plant compounds with pure THC or CBD. The extract clearly worked better -- suggesting possible synergy between the plant compounds, including cannabinoids and other components such as terpenes.
Free abstract and full text available for a fee at http://www3.interscience.wiley.com/journal/117943134/abstract.
